Across TCGA patient cohorts, LRBA mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRBA-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and 4E-BP1. Each is linked with LRBA in more than 2 cancer types. Because this analysis shows association rather than direction, both LRBA-to-partner and partner-to-LRBA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRBA→partner) and Y-score (partner→LRBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.765	+1.882	.021	.031	3	3
COAD	ASNS →	+0.655	+2.459	<.001	.018	3	3
UCEC	4E-BP1 →	+0.354	+1.621	<.001	<.001	3	3
UCEC	Notch1 →	+0.138	+1.478	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.307	-1.241	.006	.012	3	3
STAD	FASN →	+0.429	+3.015	.010	.018	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

LRBA survival (RNA) · tumor vs normal (RNA) · all LRBA data types