Across TCGA cell cohorts, LRBA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,487 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRBA-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, DNA alkylation repair, and Endosomal lumen acidification. Each is linked with LRBA in more than 12 cancer types. Because this analysis shows association rather than direction, both LRBA-to-partner and partner-to-LRBA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRBA→partner) and Y-score (partner→LRBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of chromosome condensation →	+0.151	+1.545	<.001	<.001	3	13
LARGE_INTESTINE	DNA alkylation repair →	+0.109	+0.804	<.001	<.001	3	11
KIDNEY	Endosomal lumen acidification →	+0.119	+0.679	.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.146	-0.860	<.001	<.001	3	10
LUNG_SCLC	Negative regulation of transcription by RNA polymerase I →	+0.104	+1.094	.002	<.001	3	10
BREAST	Regulation of lipophagy →	+0.169	+1.173	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,487 associations by consensus.

Exploration

LRBA survival (RNA) · tumor vs normal (RNA) · all LRBA data types