Across TCGA cell cohorts, LRBA mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRBA-associated genes across cancer lineages are OLIG3, ACTR6, and SCN2B. Each is linked with LRBA in more than 2 cancer types. Because this analysis shows association rather than direction, both LRBA-to-partner and partner-to-LRBA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRBA→partner) and Y-score (partner→LRBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OLIG3 →	+1.067	+3.624	<.001	.005	3	3
LARGE_INTESTINE	ACTR6 →	+0.544	+2.244	.001	.003	3	3
BLOOD_Myeloma	SCN2B →	+0.010	+3.754	<.001	.002	3	2
URINARY_TRACT	FAM71E2 →	+0.007	+2.736	<.001	.007	3	2
URINARY_TRACT	SLC5A8 →	+0.004	+3.044	<.001	.004	3	2
URINARY_TRACT	MYOCOS →	+0.010	+2.736	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

Exploration

LRBA survival (RNA) · tumor vs normal (RNA) · all LRBA data types