LRATD2

Across TCGA patient cohorts, LRATD2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRATD2-associated genes across cancer lineages are ERK2, MEK1, and SF2. Each is linked with LRATD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRATD2-to-partner and partner-to-LRATD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LRATD2-low versus LRATD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRATD2→partner) and Y-score (partner→LRATD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.230	+2.584	.010	.011	3	1
UCEC	MEK1 →	+0.420	+3.459	.013	.005	3	1
UCEC	SF2 →	-0.169	-2.990	<.001	.036	3	1
UCEC	Caspase-8 →	-0.275	-2.973	.019	.035	3	1
UCEC	4E-BP1 →	+0.371	+3.199	.003	.009	3	1
UCEC	CDK1_pY15 →	+0.206	+2.829	.040	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by LRATD2 expression — UCEC

Explore this box plot interactively →