LRAT

Across TCGA patient cohorts, LRAT mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRAT-associated genes across cancer lineages are C1DP2, COX6CP12, and USP9YP2. Each is linked with LRAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LRAT-to-partner and partner-to-LRAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1DP2 grouped by LRAT-low versus LRAT-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRAT→partner) and Y-score (partner→LRAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	C1DP2 →	+0.209	+3.625	<.001	.008	3	2
BRCA	COX6CP12 →	+0.371	+4.815	<.001	.001	3	2
UCEC	USP9YP2 →	+0.017	+5.066	<.001	.001	3	2
UCEC	RNU6-1114P →	+0.594	+1.769	<.001	.008	3	2
HNSC	RNA5SP73 →	+0.330	+5.015	.007	.009	3	2
UCEC	SCGB1D1 →	+1.364	+2.332	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

C1DP2 by LRAT expression — STAD

Explore this box plot interactively →