LRAT

Across TCGA patient cohorts, LRAT mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRAT-associated genes across cancer lineages are Ku80, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with LRAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LRAT-to-partner and partner-to-LRAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by LRAT-low versus LRAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRAT→partner) and Y-score (partner→LRAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.222	+2.128	.031	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.624	+2.479	.016	.010	3	2
UCEC	EGFR_pY1068 →	-0.250	-2.807	.022	.003	3	1
UCEC	GATA6 →	-0.158	-2.321	.023	.034	3	1
UCEC	INPP4B →	-0.313	-2.459	.026	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-3.459	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Ku80 by LRAT expression — UCEC

Explore this box plot interactively →