LRAT

Across TCGA cell cohorts, LRAT mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRAT-associated genes across cancer lineages are TSHB, SPIC, and BTNL2. Each is linked with LRAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LRAT-to-partner and partner-to-LRAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by LRAT-low versus LRAT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRAT→partner) and Y-score (partner→LRAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSHB →	+0.066	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SPIC →	+0.296	+4.095	<.001	.009	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TEX53 →	+0.123	+4.684	<.001	.002	3	1
BLOOD_Leukemia	CALHM4 →	+0.019	+5.269	.004	<.001	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TSHB by LRAT expression — LARGE_INTESTINE

Explore this box plot interactively →