LPXN

Across TCGA pan-cancer cohorts, LPXN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LPXN data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LPXN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LPXN expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

COAD, PDAC, and HNSC are the cancer types where LPXN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.872	1.000	.012	90	view →
PDAC	DFS	Median	All	0.934	0.672	.001	32	view →
HNSC	DFS	Tertile	II,III,IV	0.876	0.989	.017	13	view →
LUAD	DFS	Tertile	All	0.795	0.454	.003	13	view →
LSCC	OS	Tertile	II,III,IV	0.558	0.951	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LPXN–COAD (DFS)

Open the COAD breakdown →