LPXN

Across TCGA pan-cancer cohorts, LPXN mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LPXN’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where LPXN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LPXN is over-expressed in tumor, although a few such as LSCC and COAD show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where LPXN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LPXN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+1.110	<.001	11	view →
HNSC	Male	All	+0.464	<.001	8	view →
LSCC	Male	All	−0.226	<.001	5	view →
PDAC	All	All	+0.313	.004	4	view →
COAD	All	II,III,IV	−0.124	.020	2	view →
LUAD	Male	III,IV	−0.277	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LPXN–CCRCC

Open the CCRCC breakdown →