LPXN

Across TCGA patient cohorts, LPXN protein abundance is significantly associated with the RNA expression of many other genes, with 19,469 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LPXN-associated genes across cancer lineages are CYTH4, APOBEC3H, and GRAP2. Each is linked with LPXN in more than 9 cancer types. Because this analysis shows association rather than direction, both LPXN-to-partner and partner-to-LPXN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LPXN versus CYTH4 in HNSC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPXN→partner) and Y-score (partner→LPXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+1.100	+0.438	<.001	<.001	3	10
OV	APOBEC3H →	+0.771	+0.539	<.001	<.001	3	10
HNSC	GRAP2 →	+0.849	+0.425	<.001	<.001	3	10
HNSC	NCF4 →	+1.029	+0.423	<.001	<.001	3	10
LSCC	CSF2RB →	+1.049	+0.587	<.001	<.001	3	10
BRCA	IL2RB →	+1.233	+0.398	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,469 associations by consensus.

LPXN vs CYTH4 — HNSC

Explore this scatter interactively →