LPXN

Across TCGA patient cohorts, LPXN mutation is significantly associated with the RNA expression of many other genes, with 1,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPXN-associated genes across cancer lineages are IGHD2-15, RNA5SP411, and BCCIP. Each is linked with LPXN in more than 1 cancer types. Because this analysis shows association rather than direction, both LPXN-to-partner and partner-to-LPXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-15 grouped by LPXN-low versus LPXN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPXN→partner) and Y-score (partner→LPXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IGHD2-15 →	+1.300	+2.623	.003	.008	3	2
UCEC	RNA5SP411 →	+1.691	+2.531	<.001	<.001	3	2
UCEC	BCCIP →	+0.398	+2.511	.006	.009	3	2
UCEC	CTNNAL1 →	+0.585	+2.108	.006	.003	3	2
UCEC	CKS2 →	+0.769	+3.700	<.001	.001	3	2
UCEC	PSMC3IP →	+0.683	+3.608	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,624 associations by consensus.

IGHD2-15 by LPXN expression — SKCM

Explore this box plot interactively →