LPXN

Across TCGA cell cohorts, LPXN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,531 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LPXN-associated GO terms across cancer lineages are Negative regulation of small GTPase mediated signal transduction, Cellular response to external stimulus, and PML body organization. Each is linked with LPXN in more than 10 cancer types. Because this analysis shows association rather than direction, both LPXN-to-partner and partner-to-LPXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of small GTPase mediated signal transduction grouped by LPXN-low versus LPXN-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPXN→partner) and Y-score (partner→LPXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of small GTPase mediated signal transduction →	+0.095	+1.357	<.001	.001	3	11
SOFT_TISSUE	Cellular response to external stimulus →	+0.093	+1.455	<.001	<.001	3	10
LIVER	PML body organization →	+0.201	+2.872	.002	.003	3	10
BONE	Positive regulation of cell junction assembly →	+0.100	+1.979	<.001	.003	3	10
BONE	Positive regulation of cell-matrix adhesion →	+0.189	+2.092	<.001	.003	3	10
BONE	Negative regulation of blood vessel morphogenesis →	+0.161	+1.964	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,531 associations by consensus.

Negative regulation of small GTPase mediated signal transduction by LPXN expression — LUNG_NSCLC_LUAD

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