Q-omics provides the consensus-scored LPP-AS1 profile across patient tissues and cancer cell-line models. LPP-AS1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LPP-AS1 is differentially expressed in 2, with the highest sampling consensus in BRCA. Additionally, LPP-AS1 RNA expression shows 7,803 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight UVM, BRCA, and HNSC as cancer lineages where LPP-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LPP-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LPP-AS1 survival associations across molecular data types. LPP-AS1 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LPP-AS1 RNA expression–survival associations across cancer types. High LPP-AS1 expression shows unfavorable associations in UVM, KIRC, KIRP and GBM, but favorable associations in BLCA and STAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for LPP-AS1 RNA expression.
This table summarizes LPP-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for LPP-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LPP-AS1 shows lower tumor expression in ESCA and higher tumor expression in BRCA. The BRCA box plot shows higher LPP-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.186, t-test p = .019).
This table shows molecular features associated with LPP-AS1 in patient tissues and cancer cell lines. In patient samples, LPP-AS1 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set.
