LPO

Across TCGA patient cohorts, LPO protein abundance is significantly associated with the RNA expression of many other genes, with 804 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LPO-associated genes across cancer lineages are POU2AF1, PNOC, and IFNG-AS1. Each is linked with LPO in more than 1 cancer types. Because this analysis shows association rather than direction, both LPO-to-partner and partner-to-LPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LPO versus POU2AF1 in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPO→partner) and Y-score (partner→LPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POU2AF1 →	+1.397	+0.965	<.001	.004	3	2
BRCA	PNOC →	+0.713	+1.207	<.001	<.001	3	2
HNSC	IFNG-AS1 →	+0.533	+0.608	.005	.005	3	2
HNSC	FER1L4 →	+0.949	+1.080	<.001	.001	3	2
LSCC	PANK3 →	-0.846	-0.471	<.001	.001	3	2
BRCA	GRAP2 →	+0.741	+0.978	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 804 associations by consensus.

LPO vs POU2AF1 — BRCA

Explore this scatter interactively →