LPO

Across TCGA patient cohorts, LPO mutation is significantly associated with the RNA expression of many other genes, with 6,461 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPO-associated genes across cancer lineages are UHRF1, ARHGAP11A, and TYW3. Each is linked with LPO in more than 3 cancer types. Because this analysis shows association rather than direction, both LPO-to-partner and partner-to-LPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by LPO-low versus LPO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPO→partner) and Y-score (partner→LPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+1.106	+2.765	<.001	<.001	3	4
UCEC	ARHGAP11A →	+0.767	+2.069	<.001	<.001	3	4
UCEC	TYW3 →	+0.471	+2.080	<.001	<.001	3	4
SKCM	GRPEL2 →	+0.507	+1.893	.001	<.001	3	4
UCEC	ORC1 →	+0.907	+2.058	<.001	<.001	3	4
UCEC	FOXM1 →	+0.988	+2.776	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,461 associations by consensus.

UHRF1 by LPO expression — UCEC

Explore this box plot interactively →