LPO

Across TCGA patient cohorts, LPO mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPO-associated genes across cancer lineages are PCNA, INPP4B, and MEK1. Each is linked with LPO in more than 2 cancer types. Because this analysis shows association rather than direction, both LPO-to-partner and partner-to-LPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by LPO-low versus LPO-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPO→partner) and Y-score (partner→LPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.393	+3.012	.002	.018	3	3
UCEC	INPP4B →	-0.225	-1.807	.037	.024	3	2
UCEC	MEK1 →	+0.302	+2.087	.013	.005	3	2
UCEC	p62 Lck ligand →	+0.345	+3.817	.001	<.001	3	2
UCEC	Shc_pY317 →	-0.217	-3.906	<.001	<.001	3	2
UCEC	ATM →	-0.574	-2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PCNA by LPO expression — COAD

Explore this box plot interactively →