LPO

Across TCGA cell cohorts, LPO RNA expression is significantly associated with the go_rna of many other GO terms, with 1,867 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LPO-associated GO terms across cancer lineages are Regulation of protein localization to nucleus, Kidney morphogenesis, and Regulation of myoblast fusion. Each is linked with LPO in more than 5 cancer types. Because this analysis shows association rather than direction, both LPO-to-partner and partner-to-LPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to nucleus grouped by LPO-low versus LPO-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPO→partner) and Y-score (partner→LPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of protein localization to nucleus →	+0.040	+0.141	.007	.008	3	5
BLOOD_Leukemia	Kidney morphogenesis →	-0.064	-1.227	<.001	<.001	3	5
STOMACH	Regulation of myoblast fusion →	+0.079	+0.069	.002	<.001	3	5
STOMACH	Negative regulation of myoblast fusion →	+0.122	+0.075	<.001	.003	3	5
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.106	+0.076	<.001	.003	3	5
LARGE_INTESTINE	Sensory perception of touch →	+0.184	+0.152	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

Regulation of protein localization to nucleus by LPO expression — OVARY

Explore this box plot interactively →