LPO

Across TCGA cell cohorts, LPO mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPO-associated genes across cancer lineages are CRT0105446, I-BET-151, and PARP_0108. Each is linked with LPO in more than 1 cancer types. Because this analysis shows association rather than direction, both LPO-to-partner and partner-to-LPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRT0105446 grouped by LPO-low versus LPO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPO→partner) and Y-score (partner→LPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRT0105446 →	+0.446	+2.652	.022	.045	3	1
LARGE_INTESTINE	I-BET-151 →	+0.471	+3.000	.019	.017	3	1
LARGE_INTESTINE	PARP_0108 →	+0.807	+2.871	.007	.021	3	1
LARGE_INTESTINE	PARP_9482 →	+0.713	+3.000	.023	.017	3	1
LARGE_INTESTINE	AZD5153 →	+0.606	+2.871	.010	.021	3	1
LARGE_INTESTINE	IRAK4_4710 →	+0.379	+2.710	.027	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CRT0105446 by LPO expression — LARGE_INTESTINE

Explore this box plot interactively →