LPL

Across TCGA patient cohorts, LPL protein abundance is significantly associated with the RNA expression of many other genes, with 5,213 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LPL-associated genes across cancer lineages are ARRB2, GLIPR2, and ALPL. Each is linked with LPL in more than 3 cancer types. Because this analysis shows association rather than direction, both LPL-to-partner and partner-to-LPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LPL versus ARRB2 in HNSC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPL→partner) and Y-score (partner→LPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARRB2 →	+0.472	+0.539	.004	.002	3	4
BRCA	GLIPR2 →	+0.725	+0.519	<.001	<.001	3	3
LSCC	ALPL →	+1.216	+0.408	<.001	<.001	3	3
BRCA	THEMIS2 →	+0.940	+0.770	<.001	<.001	3	3
LSCC	FXYD6 →	+0.712	+0.458	.001	<.001	3	3
BRCA	FAM107A →	+1.357	+0.715	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,213 associations by consensus.

LPL vs ARRB2 — HNSC

Explore this scatter interactively →