LPL

Across TCGA patient cohorts, LPL mutation is significantly associated with the RNA expression of many other genes, with 1,452 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPL-associated genes across cancer lineages are FDFT1, CHP1, and PKN3. Each is linked with LPL in more than 3 cancer types. Because this analysis shows association rather than direction, both LPL-to-partner and partner-to-LPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FDFT1 grouped by LPL-low versus LPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPL→partner) and Y-score (partner→LPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FDFT1 →	+0.446	+2.354	.005	<.001	3	4
UCEC	CHP1 →	+0.419	+2.021	.001	.005	3	3
UCEC	PKN3 →	+0.597	+2.010	<.001	<.001	3	3
UCEC	SFXN1 →	+0.403	+2.243	.001	.001	3	3
UCEC	FUT10 →	+0.360	+2.617	.004	<.001	3	3
UCEC	TOP3A →	+0.433	+2.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,452 associations by consensus.

FDFT1 by LPL expression — UCEC

Explore this box plot interactively →