LPL

Across TCGA patient cohorts, LPL mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPL-associated genes across cancer lineages are A-Raf_pS299, MEK1, and AMPK_pT172. Each is linked with LPL in more than 1 cancer types. Because this analysis shows association rather than direction, both LPL-to-partner and partner-to-LPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by LPL-low versus LPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPL→partner) and Y-score (partner→LPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.092	-1.700	.030	.042	3	2
UCEC	MEK1 →	+0.307	+2.321	.017	.005	3	2
UCEC	AMPK_pT172 →	+0.325	+2.013	.025	.001	3	2
UCEC	INPP4B →	-0.343	-2.379	.002	<.001	3	1
UCEC	Notch1 →	+0.194	+2.916	<.001	<.001	3	1
UCEC	p27_pT198 →	+0.093	+2.321	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

A-Raf_pS299 by LPL expression — UCEC

Explore this box plot interactively →