LPL

Across TCGA cell cohorts, LPL RNA expression is significantly associated with the go_rna of many other GO terms, with 1,674 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LPL-associated GO terms across cancer lineages are Chylomicron remodeling, Axoneme assembly, and Purine ribonucleoside triphosphate metabolic process. Each is linked with LPL in more than 12 cancer types. Because this analysis shows association rather than direction, both LPL-to-partner and partner-to-LPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chylomicron remodeling grouped by LPL-low versus LPL-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPL→partner) and Y-score (partner→LPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Chylomicron remodeling →	+2.150	+3.695	<.001	<.001	3	13
LUNG_SCLC	Axoneme assembly →	-0.042	-2.471	.004	.005	2	8
SKIN	Purine ribonucleoside triphosphate metabolic process →	+0.066	+1.670	.001	.006	3	7
UPPER_AERODIGESTIVE_TRACT	Aerobic electron transport chain →	+0.073	+0.206	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic translation →	+0.082	+0.341	.002	.009	3	7
CNS	Low-density lipoprotein particle mediated signaling →	-0.189	-1.209	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,674 associations by consensus.

Chylomicron remodeling by LPL expression — LUNG_SCLC

Explore this box plot interactively →