LPIN3

Across TCGA pan-cancer cohorts, LPIN3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LPIN3 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LPIN3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LPIN3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where LPIN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.985	0.640	.041	4	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.659	.005	4	view →
LSCC	OS	Median	II,III,IV	0.863	0.609	.023	3	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LPIN3–HNSC (DFS)

Open the HNSC breakdown →