LPIN3

Across TCGA cell cohorts, LPIN3 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPIN3-associated genes across cancer lineages are ASB17, NPVF, and MC3R. Each is linked with LPIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPIN3-to-partner and partner-to-LPIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by LPIN3-low versus LPIN3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPIN3→partner) and Y-score (partner→LPIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	2
LUNG_NSCLC_LUSC	NPVF →	+0.032	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	MC3R →	+0.467	+4.108	.006	.005	3	1
LUNG_NSCLC_LUSC	CCL19 →	+0.113	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	GSTA3 →	+0.058	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	OR1G1 →	+0.085	+4.108	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

ASB17 by LPIN3 expression — OVARY

Explore this box plot interactively →