LPGAT1

Across TCGA patient cohorts, LPGAT1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPGAT1-associated genes across cancer lineages are TFRC, Bak, and c-Met_pY1235. Each is linked with LPGAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPGAT1-to-partner and partner-to-LPGAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by LPGAT1-low versus LPGAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPGAT1→partner) and Y-score (partner→LPGAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.571	+2.392	.002	<.001	3	2
UCEC	Bak →	+0.202	+1.662	.022	.011	3	2
UCEC	c-Met_pY1235 →	+0.061	+1.495	.019	.034	3	2
UCEC	EGFR →	-0.175	-2.115	.001	.017	3	1
UCEC	eIF4E →	+0.154	+2.472	.039	.010	3	1
UCEC	eIF4G →	+0.273	+2.999	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TFRC by LPGAT1 expression — UCEC

Explore this box plot interactively →