LPCAT3

Across TCGA patient cohorts, LPCAT3 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPCAT3-associated genes across cancer lineages are SLCO1B3, DNAJB5P1, and FRG2GP. Each is linked with LPCAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPCAT3-to-partner and partner-to-LPCAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1B3 grouped by LPCAT3-low versus LPCAT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT3→partner) and Y-score (partner→LPCAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLCO1B3 →	+0.515	+3.098	.007	<.001	3	2
UCEC	DNAJB5P1 →	+0.147	+1.858	<.001	.005	3	2
KIRC	FRG2GP →	+0.075	+5.509	<.001	.004	3	2
KIRC	MIR4643 →	+0.362	+5.199	.002	.007	3	2
LIHC	RNU6-91P →	+0.353	+6.902	<.001	<.001	3	1
LIHC	MIR6880 →	+0.522	+5.647	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

SLCO1B3 by LPCAT3 expression — UCEC

Explore this box plot interactively →