LPCAT3

Across TCGA patient cohorts, LPCAT3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPCAT3-associated genes across cancer lineages are ERK2, HER3, and ACVRL1. Each is linked with LPCAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPCAT3-to-partner and partner-to-LPCAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LPCAT3-low versus LPCAT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT3→partner) and Y-score (partner→LPCAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.247	+3.169	.002	.018	3	1
UCEC	HER3 →	+0.259	+2.820	.026	.035	3	1
UCEC	ACVRL1 →	-0.125	-2.986	.030	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.893	.007	.001	3	1
UCEC	JNK2 →	+0.297	+2.196	<.001	.032	3	1
UCEC	MSH2 →	-0.341	-3.575	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ERK2 by LPCAT3 expression — UCEC

Explore this box plot interactively →