LPCAT2

Across TCGA patient cohorts, LPCAT2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPCAT2-associated genes across cancer lineages are ASNS, FASN, and JNK2. Each is linked with LPCAT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LPCAT2-to-partner and partner-to-LPCAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LPCAT2-low versus LPCAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT2→partner) and Y-score (partner→LPCAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.526	+2.000	<.001	.030	3	3
UCEC	FASN →	+0.333	+1.700	.047	.044	3	1
UCEC	JNK2 →	+0.197	+2.222	.019	.011	3	1
UCEC	Myosin-IIa_pS1943 →	+0.179	+1.713	.041	.027	3	1
UCEC	p21 →	+0.196	+3.459	.016	.005	3	1
UCEC	p70-S6K →	+0.171	+2.248	.036	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ASNS by LPCAT2 expression — UCEC

Explore this box plot interactively →