LPCAT1

Across TCGA cell cohorts, LPCAT1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LPCAT1-associated genes across cancer lineages are SIGLEC11, ENPP6, and OR52H1. Each is linked with LPCAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPCAT1-to-partner and partner-to-LPCAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC11 grouped by LPCAT1-low versus LPCAT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT1→partner) and Y-score (partner→LPCAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC11 →	+0.029	+4.584	<.001	.003	3	1
LARGE_INTESTINE	ENPP6 →	+0.062	+3.793	<.001	.007	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+4.347	<.001	.001	3	1
BLOOD_Lymphoma	FAM83C →	+0.093	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	ZAN →	+0.033	+3.954	<.001	.005	3	1
BLOOD_Lymphoma	LCN9 →	+0.018	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SIGLEC11 by LPCAT1 expression — LARGE_INTESTINE

Explore this box plot interactively →