LPAR6

Across TCGA patient cohorts, LPAR6 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR6-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and p38-MAPK_pT180_Y182. Each is linked with LPAR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPAR6-to-partner and partner-to-LPAR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LPAR6-low versus LPAR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR6→partner) and Y-score (partner→LPAR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.222	-2.308	.008	.036	3	1
UCEC	Notch1 →	+0.189	+2.321	.007	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.546	-3.169	.015	.019	3	1
UCEC	Rad50 →	-0.251	-2.321	.039	.035	3	1
UCEC	STAT3_pY705 →	-0.608	-3.459	<.001	.005	3	1
UCEC	VHL →	-1.360	-3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK_pT183_Y185 by LPAR6 expression — UCEC

Explore this box plot interactively →