Across TCGA patient cohorts, LPAR5 mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR5-associated genes across cancer lineages are H2BC1, IGHD5-24, and MIR663B. Each is linked with LPAR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPAR5-to-partner and partner-to-LPAR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR5→partner) and Y-score (partner→LPAR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	H2BC1 →	+0.148	+6.339	<.001	.001	3	2
HNSC	IGHD5-24 →	+2.294	+5.015	<.001	.009	3	2
HNSC	MIR663B →	+0.434	+5.435	<.001	.005	3	2
UCEC	RNU2-50P →	+0.305	+2.423	.008	.003	3	2
UCEC	RPS10P21 →	+0.226	+2.202	.003	.005	3	2
HNSC	IGHD1-20 →	+1.192	+5.015	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

Exploration

LPAR5 survival (RNA) · tumor vs normal (RNA) · all LPAR5 data types