LPAR4

Across TCGA patient cohorts, LPAR4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR4-associated genes across cancer lineages are 53BP1, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with LPAR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LPAR4-to-partner and partner-to-LPAR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 53BP1 grouped by LPAR4-low versus LPAR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR4→partner) and Y-score (partner→LPAR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	53BP1 →	+0.254	+2.321	.029	.005	3	3
LUSC	Caspase-7-cleavedD198 →	+0.474	+2.179	.043	.035	3	2
SKCM	Cyclin-B1 →	+0.383	+2.182	.016	.033	3	2
SKCM	E-Cadherin →	-0.716	-1.584	.036	.035	3	2
UCEC	JNK2 →	+0.299	+2.916	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.298	+1.775	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

53BP1 by LPAR4 expression — UCEC

Explore this box plot interactively →