LPAR3

Across TCGA patient cohorts, LPAR3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR3-associated genes across cancer lineages are Akt_pT308, p62 Lck ligand, and Tuberin_pT1462. Each is linked with LPAR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LPAR3-to-partner and partner-to-LPAR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by LPAR3-low versus LPAR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR3→partner) and Y-score (partner→LPAR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.507	+2.321	.045	.033	3	3
UCEC	p62 Lck ligand →	+0.349	+2.415	.007	.003	3	2
UCEC	Tuberin_pT1462 →	+0.296	+1.594	.001	.042	3	2
UCEC	Ku80 →	+0.215	+1.498	.023	.036	3	1
UCEC	Notch1 →	+0.210	+2.472	<.001	.010	3	1
UCEC	PCNA →	+0.239	+3.321	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Akt_pT308 by LPAR3 expression — UCEC

Explore this box plot interactively →