LPAR3

Across TCGA cell cohorts, LPAR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,080 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible LPAR3-associated GO terms across cancer lineages are Dopamine uptake involved in synaptic transmission, rRNA transcription, and Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with LPAR3 in more than 8 cancer types. Because this analysis shows association rather than direction, both LPAR3-to-partner and partner-to-LPAR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dopamine uptake involved in synaptic transmission grouped by LPAR3-low versus LPAR3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR3→partner) and Y-score (partner→LPAR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Dopamine uptake involved in synaptic transmission →	+0.846	+0.733	<.001	<.001	3	9
OESOPHAGUS	rRNA transcription →	+0.112	+2.433	.003	<.001	3	8
LIVER	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.124	+1.760	.001	.003	3	8
OESOPHAGUS	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.118	+1.638	<.001	.003	3	8
STOMACH	Protein localization to nucleus →	+0.069	+1.463	<.001	.004	3	7
OESOPHAGUS	Nuclear transport →	+0.075	+2.005	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,080 associations by consensus.

Dopamine uptake involved in synaptic transmission by LPAR3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →