LPAR2

Across TCGA patient cohorts, LPAR2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, XBP1, and eIF4G. Each is linked with LPAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPAR2-to-partner and partner-to-LPAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by LPAR2-low versus LPAR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR2→partner) and Y-score (partner→LPAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.405	+1.906	.047	.016	3	2
UCEC	XBP1 →	-0.169	-2.687	.003	.005	3	2
UCEC	eIF4G →	+0.330	+3.321	.008	.010	3	1
UCEC	ER-alpha →	+0.727	+2.183	.027	.033	3	1
UCEC	FASN →	+0.437	+1.906	.005	.016	3	1
UCEC	JNK2 →	+0.278	+3.196	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Acetyl-a-Tubulin-Lys40 by LPAR2 expression — UCEC

Explore this box plot interactively →