LPAR2

Across TCGA cell cohorts, LPAR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,744 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LPAR2-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with LPAR2 in more than 11 cancer types. Because this analysis shows association rather than direction, both LPAR2-to-partner and partner-to-LPAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by LPAR2-low versus LPAR2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR2→partner) and Y-score (partner→LPAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.113	+0.840	.002	.003	3	12
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.113	+0.840	.002	.003	3	12
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.115	+1.384	<.001	<.001	3	11
BONE	Negative regulation of transcription elongation by RNA polymerase II →	+0.119	+1.794	<.001	<.001	3	11
KIDNEY	Regulation of myoblast fusion →	+0.100	+1.354	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.053	+0.927	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,744 associations by consensus.

Negative regulation of DNA-templated transcription initiation by LPAR2 expression — LARGE_INTESTINE

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