LPAR2

Across TCGA cell cohorts, LPAR2 mutation is significantly associated with the RNA expression of many other genes, with 1,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPAR2-associated genes across cancer lineages are GGA1, CENPM, and POLDIP3. Each is linked with LPAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPAR2-to-partner and partner-to-LPAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGA1 grouped by LPAR2-low versus LPAR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR2→partner) and Y-score (partner→LPAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GGA1 →	+0.690	+2.502	<.001	.005	3	1
LARGE_INTESTINE	CENPM →	+0.787	+2.502	<.001	.005	3	1
LARGE_INTESTINE	POLDIP3 →	+0.525	+3.192	.005	.007	3	1
LARGE_INTESTINE	PPP6R2 →	+0.554	+3.169	.007	.009	3	1
LARGE_INTESTINE	TAB1 →	+0.584	+3.237	.002	.003	3	1
LARGE_INTESTINE	TNRC6B →	+0.837	+3.628	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,112 associations by consensus.

GGA1 by LPAR2 expression — LARGE_INTESTINE

Explore this box plot interactively →