Across TCGA patient cohorts, LPAR1 mutation is significantly associated with the RNA expression of many other genes, with 3,007 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR1-associated genes across cancer lineages are MIR6870, H2BC17, and IGHD5-12. Each is linked with LPAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPAR1-to-partner and partner-to-LPAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR1→partner) and Y-score (partner→LPAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6870 →	+0.245	+1.981	.003	.003	3	2
UCEC	H2BC17 →	+0.640	+3.839	.002	<.001	3	2
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	2
READ	APOOP2 →	+0.655	+5.039	<.001	.008	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
GBM	RNU6-787P →	+0.719	+5.352	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,007 associations by consensus.

Exploration

LPAR1 survival (RNA) · tumor vs normal (RNA) · all LPAR1 data types