Across TCGA patient cohorts, LPAR1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAR1-associated genes across cancer lineages are eIF4E, Cyclin-B1, and Cyclin-E2. Each is linked with LPAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPAR1-to-partner and partner-to-LPAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAR1→partner) and Y-score (partner→LPAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.161	+3.183	.037	.009	3	2
UCEC	Cyclin-B1 →	+0.740	+3.700	<.001	.001	3	2
UCEC	Cyclin-E2 →	+0.132	+1.502	.033	.030	3	2
UCEC	ERK2 →	+0.177	+2.247	.012	.001	3	1
UCEC	JNK2 →	+0.171	+3.026	.019	.018	3	1
UCEC	Ku80 →	+0.199	+1.515	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

LPAR1 survival (RNA) · tumor vs normal (RNA) · all LPAR1 data types