Across TCGA patient cohorts, LPAL2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPAL2-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and FASN. Each is linked with LPAL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LPAL2-to-partner and partner-to-LPAL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPAL2→partner) and Y-score (partner→LPAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.310	+1.906	.014	.015	3	3
UCEC	Caspase-7-cleavedD198 →	+0.589	+2.242	.004	.005	3	3
UCEC	FASN →	+0.363	+2.000	.007	.030	3	2
UCEC	GSK-3_pS9 →	-0.336	-1.700	.016	.040	3	2
UCEC	mTOR_pS2448 →	-0.124	-2.209	.016	.009	3	2
UCEC	Annexin-1 →	+0.604	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

LPAL2 survival (RNA) · tumor vs normal (RNA) · all LPAL2 data types