Across TCGA pan-cancer cohorts, LPA Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated LPA data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher LPA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LPA expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.
UCS, LUAD, and SKCM are the cancer types where LPA Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.