Across TCGA patient cohorts, LPA protein abundance is significantly associated with the RNA expression of many other genes, with 4,921 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LPA-associated genes across cancer lineages are PTGS2, FCAR, and MEDAG. Each is linked with LPA in more than 4 cancer types. Because this analysis shows association rather than direction, both LPA-to-partner and partner-to-LPA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPA→partner) and Y-score (partner→LPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTGS2 →	+1.340	+0.526	<.001	.001	3	5
PDAC	FCAR →	+0.607	+1.210	<.001	<.001	3	4
LSCC	MEDAG →	+0.902	+0.575	.002	.001	3	4
GBM	AQP9 →	+1.100	+0.640	<.001	.008	3	4
GBM	CCL3 →	+1.214	+0.810	.001	.002	3	4
LSCC	TREM1 →	+0.680	+0.352	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,921 associations by consensus.

Exploration

LPA survival (RNA) · tumor vs normal (RNA) · all LPA data types