Across TCGA patient cohorts, LPA mutation is significantly associated with the RNA expression of many other genes, with 5,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPA-associated genes across cancer lineages are COX7A2, PBK, and DTYMK. Each is linked with LPA in more than 5 cancer types. Because this analysis shows association rather than direction, both LPA-to-partner and partner-to-LPA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPA→partner) and Y-score (partner→LPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX7A2 →	+0.290	+1.709	<.001	.001	3	6
UCEC	PBK →	+0.843	+2.233	<.001	<.001	3	5
UCEC	DTYMK →	+0.552	+2.099	<.001	<.001	3	5
LUAD	ZWILCH →	+0.539	+1.856	<.001	.004	3	5
LUAD	DEPDC1 →	+0.739	+1.777	<.001	.002	3	5
LUAD	NCAPG →	+0.897	+2.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,812 associations by consensus.

Exploration

LPA survival (RNA) · tumor vs normal (RNA) · all LPA data types