LPA

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, LPA mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LPA-associated genes across cancer lineages are HTR1E, NLRP8, and KLHL34. Each is linked with LPA in more than 1 cancer types. Because this analysis shows association rather than direction, both LPA-to-partner and partner-to-LPA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPA→partner) and Y-score (partner→LPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PANCREASHTR1E →+0.062+3.491<.001.00832
UPPER_AERODIGESTIVE_TRACTNLRP8 →+0.037+4.357<.001.00632
OESOPHAGUSKLHL34 →+0.013+4.906<.001.00632
OESOPHAGUSPPIAL4F →+0.060+4.906<.001.00632
LUNG_SCLCOR56A1 →+0.078+3.987<.001.00932
BLOOD_LeukemiaCYB5A →+1.431+3.228.001.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

Exploration