LOXL3

Across TCGA patient cohorts, LOXL3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,069 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LOXL3-associated genes across cancer lineages are SERPINE1, COL6A3, and MSRB3. Each is linked with LOXL3 in more than 6 cancer types. Because this analysis shows association rather than direction, both LOXL3-to-partner and partner-to-LOXL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LOXL3 versus SERPINE1 in GBM, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL3→partner) and Y-score (partner→LOXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINE1 →	+1.667	+0.390	<.001	<.001	3	7
OV	COL6A3 →	+1.530	+0.575	.003	<.001	3	7
UCEC	MSRB3 →	+0.956	+0.597	<.001	<.001	3	7
UCEC	MYL9 →	+1.418	+0.650	<.001	<.001	3	6
LSCC	SPARC →	+0.864	+0.487	<.001	<.001	3	6
UCEC	TSHZ3 →	+0.803	+0.410	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,069 associations by consensus.

LOXL3 vs SERPINE1 — GBM

Explore this scatter interactively →