LOXL3

Across TCGA patient cohorts, LOXL3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXL3-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and JNK2. Each is linked with LOXL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LOXL3-to-partner and partner-to-LOXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by LOXL3-low versus LOXL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL3→partner) and Y-score (partner→LOXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.469	+3.321	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.866	+1.765	<.001	.014	3	3
UCEC	JNK2 →	+0.265	+2.169	<.001	.003	3	2
UCEC	ASNS →	+0.357	+1.807	.008	.025	3	2
UCEC	ATM →	-0.453	-2.662	.007	<.001	3	2
UCEC	4E-BP1 →	+0.239	+3.169	.018	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by LOXL3 expression — UCEC

Explore this box plot interactively →