LOXL3

Across TCGA cell cohorts, LOXL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,839 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LOXL3-associated GO terms across cancer lineages are Regulation of cell cycle G2/M phase transition, Regulation of double-strand break repair, and Cell cycle phase transition. Each is linked with LOXL3 in more than 9 cancer types. Because this analysis shows association rather than direction, both LOXL3-to-partner and partner-to-LOXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle G2/M phase transition grouped by LOXL3-low versus LOXL3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL3→partner) and Y-score (partner→LOXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of cell cycle G2/M phase transition →	+0.085	+1.026	.002	.005	3	10
OESOPHAGUS	Regulation of double-strand break repair →	+0.102	+1.299	<.001	<.001	3	10
LARGE_INTESTINE	Cell cycle phase transition →	+0.077	+1.135	<.001	<.001	3	10
OESOPHAGUS	Negative regulation of gene expression, epigenetic →	+0.069	+1.274	<.001	.003	3	10
LARGE_INTESTINE	Microtubule polymerization or depolymerization →	+0.101	+0.813	<.001	<.001	3	10
OESOPHAGUS	rRNA transcription →	+0.166	+1.527	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,839 associations by consensus.

Regulation of cell cycle G2/M phase transition by LOXL3 expression — OESOPHAGUS

Explore this box plot interactively →