LOXL3

Across TCGA cell cohorts, LOXL3 mutation is significantly associated with the RNA expression of many other genes, with 760 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LOXL3-associated genes across cancer lineages are ACER1, OR1J1, and OR1J2. Each is linked with LOXL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL3-to-partner and partner-to-LOXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by LOXL3-low versus LOXL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL3→partner) and Y-score (partner→LOXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.081	+2.308	<.001	.002	3	2
BLOOD_Leukemia	OR1J1 →	+0.240	+3.526	<.001	.008	3	2
BLOOD_Leukemia	OR1J2 →	+0.052	+2.991	.005	.007	3	2
BLOOD_Lymphoma	CBLIF →	+0.052	+3.192	.003	.008	3	1
BLOOD_Lymphoma	KLHL40 →	+0.004	+4.209	.004	.001	3	1
BLOOD_Lymphoma	WFDC13 →	+0.072	+3.342	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

ACER1 by LOXL3 expression — LARGE_INTESTINE

Explore this box plot interactively →