LOXL2

Across TCGA patient cohorts, LOXL2 mutation is significantly associated with the RNA expression of many other genes, with 3,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXL2-associated genes across cancer lineages are CBX3P8, MZT1, and ATF4P3. Each is linked with LOXL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LOXL2-to-partner and partner-to-LOXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX3P8 grouped by LOXL2-low versus LOXL2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL2→partner) and Y-score (partner→LOXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	CBX3P8 →	+0.079	+7.939	<.001	.008	3	3
UCEC	MZT1 →	+0.644	+2.593	<.001	<.001	3	3
UCEC	ATF4P3 →	+0.279	+1.922	<.001	.001	3	3
UCEC	SCARNA22 →	+0.775	+1.736	<.001	<.001	3	3
UCEC	SNHG21 →	+0.354	+1.358	.004	.004	3	3
UCEC	SAP18 →	+0.235	+2.297	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

CBX3P8 by LOXL2 expression — PRAD

Explore this box plot interactively →