LOXL2

Across TCGA patient cohorts, LOXL2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXL2-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk2_pT68, and INPP4B. Each is linked with LOXL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LOXL2-to-partner and partner-to-LOXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LOXL2-low versus LOXL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL2→partner) and Y-score (partner→LOXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.392	+1.697	.036	.012	3	3
UCEC	Chk2_pT68 →	-0.153	-3.781	.009	<.001	3	3
UCEC	INPP4B →	-0.235	-1.807	.021	.003	3	2
UCEC	MEK1 →	+0.415	+2.115	<.001	<.001	3	2
UCEC	Rad50 →	-0.291	-2.986	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.117	-1.353	.014	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by LOXL2 expression — UCEC

Explore this box plot interactively →